Research in the Environmental Chemistry and Toxicology Laboratory emphasizes pesticide mode of action and metabolism. This information is important to optimize pesticide use, improve their selectivity and environmental characteristics, and minimize the hazards of exposure for humans, domestic animals and other nontarget species. Recent research is illustrated in the publications below.
Casida, J.E., Durkin, K.A. (2017) Pesticide chemical research in toxicology: Lessons from nature. Chem. Res. Toxicol., 30: 94-104.
Peng, Y., Sheng, C., Casida, J. E., Zhao, C., & Han, Z. (2017). Ryanodine receptor genes of the rice stem borer, Chilo suppressalis: Molecular cloning, alternative splicing and expression profiling. Pestic. Biochem. Physiol., 135: 69-77.
Casida, J.E. (2016) Unexpected metabolic reactions and secondary targets of pesticide action. J. Agric. Food Chem. 64: 4471–4477
Casida, J.E. (2015) Golden age of RyR and GABA-R diamide and isoxazoline insecticides: common genesis, serendipity, surprises, selectivity, and safety. Chem. Res. Toxicol. 28: 560-6.
Zhao, C., Hwang S.H., Buchholz, B. Lightstone, F.C., Carpenter, T.S., Yang, J., Hammock, B.D., Casida, J.E. (2014) The GABAa receptor target of tetramethylenedisulfotetramine. Proc. Natl. Acad. Sci. USA 111: 8607-12
Lantz, S.R, Mack, C.M., Wallace, K., Key, E.F. Shafer, T.J., Casida, J.E. (2014) Glufosinate neurotoxicity mediated in part by N-methyl-D-aspartate receptor activation. J. Agric. Food Chem. 45: 38-47
Wang, Y., Guo, L., Qi, S. Zhang, H., Liu, R., Liang, P. Casida, J.E. Shangzhong, L. (2014) Development of a fluorescence polarization binding assay for insect ryanodine receptor. Molecules 19: 4105-4114
Zhao C., Casida, J.E. (2014) Insect γ-aminobutyric acid receptors and isoxazoline insecticides: toxicological profiles relative to the binding sites of [3H]fluralaner, [3H]-4’-ethynyl-4-n-propylbicycloorthobenzoate, and [3H]avermectin. J. Agric. Food Chem. 62: 1019-1024.
Shao, X. Swenson, T. Casida, J.E. (2013) Cycloxaprid insecticide: nicotinic acetylcholine receptor binding site and metabolism. J. Agric. Food Chem. 61: 7883-7888
Lantz, S., Casida, J.E. (2013) Characterization of the transient oxaphosphetane BChE inhibitor formed from spontaneously-activated ethephon. Chem. Res. Tox. 26: 1320-1322
Swenson, T.L, Casida, J.E. (2013) Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice. Toxicol. Sci. 132:22-28
Liyasova, M.S. Schopfer, L.M. Kodani, S. Lantz, S.R., Casida, J.E., Lockridge, O. (2013) Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor. Chem. Res. Toxicol. 26:422-431